System-level understanding of EC coupling process in Heart
Systemic Research of calcium homeostasis & disease development in heart
EDUCATION
1981 Marquette Univ. (Ph. D. - Biology, Molecular Physiology)
1977 Seoul National Univ. (M.S. - Zoology, Physiology)
1973 Seoul National Univ. (B.S. - Zoology)
WORK EXPERIENCE
2003 - present Systemes Biology Research Group, Director
2001 - Korean Nanobiotechnology Research Center, Co-director
2000 - The National Program of Critical Technology 21
on "Life Phenomena and Function Research", Director
1994 - present GIST, Professor
1988 - Harvard Medical School, Visiting professor
1986 - 1995 Univ. of Connecticut, Assistant professor, Associate professor
1982 - 1986 Boston Biomedical Research Institute, Postdoctorial fellow
REPRESENTATIVE_PUBLICATIONS
Lee, E.H., Rho, S.H., Kwon, S.J., Eom, S.H., Allen, P.D. and Kim, D.H.(2004) N-terminal region of FKBP12 is essential for binding to the skeletal ryanodine receptor. J. Biol. Chem., Jun 18;279(25):26481-8
Lee JM, Rho SH, Shin DW, Cho C, Park WJ, Eom SH, Ma J, Kim do H.(2004) Negatively charged amino acids within the intraluminal loop of ryanodine receptor are involved in the interaction with triadin. J Biol. Chem. Feb 20;279(8):6994-7000
Jung, D.H. and Kim, D.H.(2004) Characterization of isoforms and genomic organization of mouse calumenin. Gene. Mar 3;327(2):185-94
Lee, J.I., Dhakal, B.K., Lee, J., Bandyopadhyay, J., Jeong, S.Y., Eom, S.H., Kim, D.H. and Ahnn, J. (2003) The Caenorhabditis elegans homologue of Down Syndrome critical region 1, RCN-1, inhibits multiple functions of the phosphase calcineurin. J. Mol. Biol. 328:147-156
Shin, D.W., Pan, Z., Lee, J.M., Bhat, M.B., Kim, D.H. and Ma, J. (2003) A retrograde signal from calsequestrin for the regulation of store-operated Ca2+ entry in skeletal muscle. J. Biol. Chem. 278:3286-3292. (D.H.K. is the corresponding author)
Choi, I., Woo, J.M., Hong, S., Jung, Y.K., Kim, D.H. and Cho, C. (2003) Identification and characterization of ADAM32 with testis-predominant gene expression. Gene. 304:151-162
Hamada, T., Sakube, Y., Ahnn, J., Kim, D.H. and Kagawa, H. (2002) Molecular dissection, tissue localization and Ca2+ binding of the ryanodine receptor of Caenorhabditis elegans, J. Mol. Biol. 324:123-135.
Bandyopadhyay, J., Lee, J., Lee, J., Lee, J.I., Yu, J. R., Jee, C., Cho, J.H., Jung, S., Lee, M.H., Zannoni, S., Singson, A., Kim, D.H., Koo, H.S. and Ahnn, J. (2002) Calcineurin, a calcium/calmodulin-dependent protein phosphatase, is involved in movement, fertility, egg laying, and growth in Caenorhabditis elegans. Mol. Biol. Cell 13:3281-3293.
Hong, C.S., Cho, M.C., Kwak, Y.G., Song, C.H, Lee, Y.H., Kwon, Y.H.K., Chae, S.W. and Kim, D.H. (2002) Cardiac remodeling and atrial fibrillation in transgenic mice overexpressing junctin. FASEB J. 16:1310-1312.
Kim, M.J., Jo, D.G., Hong, G.S., Kim, B.J., Lai, M., Cho, D.H., Kim, K.W., Bandyopadhyay, A., Hong, Y.M., Kim, D.H., Liu, J., Snyder, S.H. and Jung, Y.K.(2002) Calpain-dependent cleavage of cain/cabin1 activates calcineurin to mediate calcium-triggered cell death. Proc. Nat. Acad. Sci. 99:9870-9875.
